Melagenina (now Melagenina Plus) was developed in Cuba about 20 years ago, using human placenta tissue. They may now use other animal placental tissues. The company in Cuba that markets it claims high success rates, but these cannot be substantiated, and many people have claimed no results at all. The product instructions indicate that application of the cream should be several times a day, followed by 15 minutes of natural sunlight. In 1998, Melagenina Plus was announced, which unlike the previous treatment requires only once daily application and does not require exposure to the sun. The company claims that the calcium chloride contained in the product strengthens the skin?s pigmentation. The product is not available in the U.S. or Canada, and is not approved by the FDA for use on vitiligo.